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The Homer1 gene is implicated in the pathogenesis of major depression through genome-wide association as well as neuroimaging studies Rietschel et al. This is particularly evident in stress-induced changes in the structure of reward network neurons. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The list of related phrases is also based on surfers search queries. Your browser does not support HTML5 video. SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability. The cortico-basal ganglia reward network The central feature of the reward circuitry is the release of dopamine DA from the ventral tegmental area VTA neurons into limbic brain regions that control prediction, perception, and processing of rewarding stimuli.
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